Substance guides
Cocaine and seizures: A neurological emergency
Published October 19, 2024 · 6 min read · Updated April 2026
Reviewed for accuracy by licensed clinical professionals.
Cocaine lowers the seizure threshold and can produce generalized tonic-clonic seizures, particularly at high doses and during binges.
Mechanism
Cocaine's effects on sodium channels and neurotransmitter systems lower the seizure threshold. Higher doses, binge patterns, and concomitant drug use increase risk. Body temperature elevation amplifies risk.
Response
Call 911 for any seizure. Protect the person from injury (clear surroundings). Do NOT put anything in their mouth. Time the seizure. Position on side after seizure stops.
Risk factors
High doses. Binge use patterns. Mixing with other drugs. Previous seizure history. Overheating.
Frequently asked questions
Can cocaine cause seizures?
Yes. Cocaine lowers seizure threshold. Risk increases with dose, binge patterns, and mixing with other substances.
What do I do if someone has a seizure?
Call 911. Protect from injury. Do NOT put anything in mouth. Time it. Position on side afterward.
Are cocaine seizures dangerous?
Yes. Seizures can cause injury, aspiration, and status epilepticus (continuous seizure) which is life-threatening.
Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.