Substance guides

How to quit opioids: Your options and next steps

Published December 5, 2024 · 8 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Quitting opioids is possible and millions have done it. The approach depends on what you are using, how long, and what resources are available.

MAT: The gold standard

Buprenorphine (Suboxone) eliminates withdrawal within hours. Can be prescribed by any physician via telehealth. Reduces overdose death by 50%. This is the recommended first-line approach for most people.

Medical detox

If you prefer to be opioid-free, medical detox manages withdrawal safely over 5-10 days. Should be followed by ongoing treatment (not detox alone). Consider naltrexone (Vivitrol) after detox to prevent relapse.

Getting started today

Call your doctor and ask about buprenorphine. Call SAMHSA at 1-800-662-4357. Use our directory to find local treatment. Telehealth MAT providers can often start same-day.

The fentanyl complication

If using fentanyl, micro-dosing buprenorphine protocols avoid precipitated withdrawal. Tell your provider you are using fentanyl so they can plan induction appropriately.

Authoritative sources

This article references guidelines from: NIDA · SAMHSA · CDC

Frequently asked questions

What is the best way to quit opioids?

MAT with buprenorphine is the gold standard. It eliminates withdrawal and reduces overdose death by 50%.

Can I quit opioids at home?

With MAT prescribed by your doctor, yes. Cold-turkey at home is possible but unnecessarily uncomfortable. Medical support is recommended.

How do I get Suboxone?

Any physician can prescribe it. Call your doctor, use SAMHSA's provider locator, or try telehealth MAT providers for same-day starts.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.