Substance guides
Opioid withdrawal medications: What helps and how
Published March 8, 2025 · 6 min read · Updated April 2026
Reviewed for accuracy by licensed clinical professionals.
Opioid withdrawal is intensely uncomfortable but rarely life-threatening. Medications significantly reduce suffering.
Buprenorphine
The gold standard. Eliminates withdrawal symptoms within 30-60 minutes. Transitions directly into ongoing MAT. Most effective single intervention.
Clonidine
Reduces autonomic symptoms: sweating, anxiety, rapid heartbeat, restlessness. Does not treat cravings. Often used alongside other medications.
Other medications
Loperamide for diarrhea. NSAIDs for muscle aches. Hydroxyzine or trazodone for insomnia. Ondansetron for nausea. Gabapentin for anxiety and restless legs. These manage specific symptoms.
Frequently asked questions
How do I find help?
Call SAMHSA at 1-800-662-4357 or search our directory.
Is treatment effective?
Yes. Evidence-based treatment works.
Does insurance cover this?
Yes under the Mental Health Parity Act.
Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.