Substance guides
Opioid constipation: Prevention and treatment guide
Published February 12, 2025 · 6 min read · Updated April 2026
Reviewed for accuracy by licensed clinical professionals.
Affects 40-80% of opioid users. Start prevention when starting opioids.
Treatment
MiraLAX, senna, fiber, hydration. Prescription: methylnaltrexone (Relistor) for refractory cases.
Frequently asked questions
How do I find help?
Call SAMHSA at 1-800-662-4357 or search our directory.
Does insurance cover this?
Most insurance covers substance abuse treatment under mental health parity.
Is treatment effective?
Yes. Treatment reduces substance use by 50-70%.
Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.