Substance guides

Signs of stimulant overdose: Cocaine, meth, and Adderall

Published October 20, 2024 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Stimulant overdose is a cardiovascular emergency, not a respiratory one. There is no reversal agent like naloxone for stimulants.

Signs

Severe chest pain. Difficulty breathing. Extreme agitation or aggression. Seizures. Body temperature above 104F (hyperthermia). Severe headache. Irregular or racing heartbeat. Confusion or psychosis. Loss of consciousness.

Response

Call 911 immediately. Keep the person as calm as possible. Cool them if overheating (remove excess clothing, apply cool water). Do NOT restrain unless there is immediate danger of injury. Do not give anything by mouth.

Key difference from opioid overdose

Stimulant overdose: agitation, seizures, hyperthermia. Opioid overdose: sedation, respiratory depression. The treatments are different. Naloxone does NOT help stimulant overdose.

Authoritative sources

This article references guidelines from: NIDA · SAMHSA · CDC

Frequently asked questions

What does a stimulant overdose look like?

Chest pain, extreme agitation, seizures, hyperthermia, racing heartbeat, and psychosis.

Is there a reversal for stimulant overdose?

No. There is no equivalent of naloxone for stimulants. Treatment is supportive medical care.

When should I call 911 for stimulant use?

Chest pain, seizures, temperature above 104F, loss of consciousness, or severe agitation all require immediate medical attention.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.