Substance guides

Sublocade: The monthly buprenorphine injection explained

Published November 8, 2025 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals. Editorial process.

Sublocade is an extended-release buprenorphine injection administered monthly, eliminating the need for daily sublingual Suboxone dosing. For many people in MAT, it represents a significant quality-of-life improvement.

How it works

Sublocade is injected subcutaneously (under the skin of the abdomen) once per month by a healthcare provider. It forms a solid depot that slowly releases buprenorphine over the month, maintaining consistent blood levels. This eliminates daily dosing decisions, removes the ritual of daily sublingual administration (which some find triggering), prevents missed doses, and reduces diversion risk (you cannot share or sell an injection in your abdomen).

Advantages over daily Suboxone

No daily dosing — one injection per month. Consistent blood levels without the peaks and troughs of sublingual dosing. Eliminates dental concerns associated with sublingual buprenorphine. Reduced stigma — no one sees you taking medication daily. Cannot be accidentally discovered by others. Simplifies travel (no need to carry medication). May improve treatment adherence for people who struggle with daily dosing consistency.

What to expect

The injection itself is given in a healthcare setting and takes about 5 minutes. A small lump may form at the injection site that gradually absorbs over the month. Side effects are similar to sublingual buprenorphine: constipation, headache, nausea. You must be stable on sublingual buprenorphine for at least 7 days before starting Sublocade. If you decide to discontinue MAT, Sublocade has a very long tail — buprenorphine levels decline gradually over months, providing a built-in slow taper that many patients find easier than tapering sublingual doses.

Insurance coverage

Sublocade is covered by most commercial insurance plans and Medicaid in most states. Without insurance, the cost is approximately $1,800-$2,000 per injection. The manufacturer offers a copay assistance program for commercially insured patients.

Treatment facilities

Shelby County Treatment Center

Alabaster, AL

Call 205-216-0200

Lighthouse of Tallapoosa County Inc

Alexander City, AL

Call 256-234-4894

South Central Alabama MHC

Andalusia, AL

Call 334-428-5050

Anniston Fellowship House Inc

Anniston, AL

Call 256-236-7229

Browse all facilities →

Authoritative sources

This article references guidelines from: SAMHSA · NIDA · ASAM

Frequently asked questions

What is Sublocade?

Sublocade is a monthly buprenorphine injection for opioid use disorder treatment. It eliminates daily dosing by slowly releasing medication from a depot under the skin.

Is Sublocade better than Suboxone?

They contain the same active ingredient. Sublocade offers advantages of monthly dosing, consistent blood levels, and no dental concerns. The best choice depends on individual preference and clinical factors.

Does insurance cover Sublocade?

Most commercial insurance and Medicaid cover Sublocade. The manufacturer offers copay assistance for commercially insured patients.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.