Substance guides

Suboxone side effects: What to expect during MAT

Published May 28, 2025 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Suboxone (buprenorphine/naloxone) is highly effective for opioid use disorder, but understanding side effects helps you stay on treatment and know when to seek help.

Common side effects

Headache. Nausea and vomiting (usually first few days). Constipation (ongoing, manageable with fiber and hydration). Sweating. Insomnia or drowsiness. Numbness or pain in mouth or tongue from sublingual administration.

Serious side effects

Respiratory depression (rare at therapeutic doses, risk increases with benzodiazepine or alcohol use). Liver problems (monitor liver function). Adrenal insufficiency (rare, chronic fatigue and weakness). Severe allergic reaction. Precipitated withdrawal if started too early.

Managing side effects

Constipation: increase fiber, fluids, and consider stool softeners. Nausea: usually resolves within the first week; take with food. Headache: typically resolves; OTC pain relievers help. Sweating: common and persistent for some; stay hydrated.

The balance

Side effects are almost always preferable to continued opioid addiction. Most are manageable and many resolve with time. Do not stop Suboxone due to side effects without consulting your prescriber.

Authoritative sources

This article references guidelines from: SAMHSA · NIDA · ASAM

Frequently asked questions

What are the most common Suboxone side effects?

Headache, nausea, constipation, sweating, and insomnia are most common. Most improve within the first 1-2 weeks.

Does Suboxone make you gain weight?

Some patients report weight gain, likely from improved appetite and nutrition in recovery rather than a direct medication effect.

Can you drink alcohol on Suboxone?

Alcohol with Suboxone increases respiratory depression risk and is strongly discouraged.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.