Substance guides

What is GHB? The club drug with deadly withdrawal

Published November 1, 2024 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

GHB (gamma-hydroxybutyrate) is a CNS depressant used recreationally for euphoria and disinhibition. Also known as G, liquid ecstasy, and fantasy. Known as a date-rape drug due to sedating properties.

Effects and overdose

Low doses: euphoria, relaxation, sociability. Higher doses: drowsiness, confusion, unconsciousness. The margin between recreational and dangerous is narrow, especially combined with alcohol.

Withdrawal is uniquely dangerous

GHB withdrawal is one of the most medically dangerous of any substance, comparable to alcohol and benzo withdrawal. Seizures, delirium, psychosis, and death can occur. Symptoms begin 1-6 hours after last dose. Medical detox is essential.

Treatment

Medical detox with benzodiazepines and/or barbiturates. ICU monitoring may be needed. Standard addiction treatment follows detox.

Authoritative sources

This article references guidelines from: NIDA · SAMHSA · CDC

Frequently asked questions

What does GHB do?

Low doses: euphoria and relaxation. High doses: unconsciousness and respiratory depression. Also used as a date-rape drug.

Is GHB withdrawal dangerous?

Extremely. GHB withdrawal can cause seizures, delirium, psychosis, and death. Medical detox is essential.

How long does GHB withdrawal last?

Acute withdrawal begins within hours and typically lasts 5-15 days. Severe cases may require ICU monitoring.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.