Substance guides
What is krokodil? The flesh-eating drug
Published November 7, 2024 · 6 min read · Updated April 2026
Reviewed for accuracy by licensed clinical professionals.
Krokodil (desomorphine) is a homemade opioid that causes severe tissue damage at injection sites due to toxic byproducts from crude synthesis.
Why it destroys tissue
Homemade synthesis leaves toxic residues (phosphorus, heavy metals, organic solvents). These cause tissue necrosis, gangrene, and bone damage at injection sites. The name comes from the scaly, greenish appearance of damaged skin.
In the US
Confirmed cases in the US are extremely rare. Most reports have been unverified. Standard opioid treatment applies.
Frequently asked questions
How do I find help?
Call SAMHSA at 1-800-662-4357 or search our directory at treatmentassociation.com/directory.
Does insurance cover treatment?
Yes. Most insurance covers substance abuse treatment under the Mental Health Parity Act.
Is this treatable?
Yes. Addiction is a treatable medical condition. Recovery is possible at any stage.
Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.