Substance guides

Gabapentin abuse: The emerging risk

Published November 25, 2024 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Gabapentin was once considered non-addictive. Emerging evidence shows significant abuse potential, particularly in people with opioid use histories.

How it is abused

High doses (3,000-5,000+ mg) produce euphoria and sedation. Combined with opioids, it amplifies the high. Some people combine it with buprenorphine to enhance effects. Available by prescription with relatively easy access.

Risks

Respiratory depression when combined with opioids or alcohol. Physical dependence with withdrawal symptoms. Seizure risk during withdrawal. Several states have classified gabapentin as a controlled substance.

Clinical implications

Monitor gabapentin use in patients with opioid histories. Drug testing panels increasingly include gabapentin. Consider alternatives for anxiety and pain in recovery populations.

Authoritative sources

This article references guidelines from: SAMHSA · NIDA · ASAM

Frequently asked questions

Is gabapentin addictive?

At prescribed doses for most patients, no. But abuse potential exists, especially at high doses and in people with opioid use histories.

Can you get high on gabapentin?

At high doses, gabapentin can produce euphoria and sedation. The effect is amplified when combined with opioids.

Is gabapentin a controlled substance?

Not federally, but several states have classified it as such due to emerging abuse patterns.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.