Substance guides

Gabapentin abuse: The growing concern

Published August 5, 2025 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Gabapentin (Neurontin) was long considered non-addictive, but mounting evidence shows significant abuse potential, particularly among people with opioid use disorder.

How it is abused

At high doses (above prescribed range), gabapentin produces euphoria, relaxation, and dissociation. It potentiates the effects of opioids, making it popular as a combination drug. Some users take 3,000-5,000mg at once (prescribed doses are typically 300-1,200mg/day).

Risk factors

People with existing substance use disorders are most likely to abuse gabapentin. It is increasingly found in overdose toxicology reports, usually in combination with opioids.

Withdrawal

Gabapentin withdrawal can include anxiety, insomnia, nausea, sweating, and in rare cases seizures. Gradual tapering is recommended for discontinuation after chronic use.

Regulatory response

Several states have reclassified gabapentin as a controlled substance. Treatment programs and pain management clinics increasingly test for it.

Authoritative sources

This article references guidelines from: SAMHSA · NIDA · ASAM

Frequently asked questions

Is gabapentin addictive?

Gabapentin has abuse potential, particularly at high doses and in people with existing substance use disorders.

Can you get high on gabapentin?

At doses well above prescribed range, gabapentin can produce euphoria and dissociation.

Is gabapentin dangerous?

Gabapentin alone is relatively safe but becomes dangerous combined with opioids, contributing to respiratory depression and overdose.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.