Substance guides

Medications used in opioid detox

Published March 22, 2025 · 7 min read · Updated April 2026

Reviewed for accuracy by licensed clinical professionals.

Opioid detox medications range from eliminating withdrawal entirely (MAT) to managing symptoms individually (comfort medications).

Buprenorphine (Suboxone)

Eliminates withdrawal symptoms and can continue as long-term MAT. Gold standard approach. Requires waiting until sufficient withdrawal develops before starting (to avoid precipitated withdrawal).

Methadone

Full agonist that eliminates withdrawal. Dispensed at licensed OTP clinics. Can continue as long-term MAT. No waiting period required.

Clonidine protocol

For patients who decline MAT. Reduces autonomic symptoms (sweating, anxiety, rapid heart rate). Does not eliminate core withdrawal symptoms. Combined with comfort medications.

Comfort medications

Loperamide (diarrhea). Ondansetron (nausea). Trazodone (insomnia). Dicyclomine (abdominal cramping). Ibuprofen (muscle aches). Hydroxyzine (anxiety).

Authoritative sources

This article references guidelines from: NIDA · SAMHSA · CDC

Frequently asked questions

What is the best medication for opioid withdrawal?

Buprenorphine (Suboxone) or methadone eliminate withdrawal entirely and should be the default approach.

Can I detox from opioids without medication?

Possible but unnecessarily uncomfortable. Medical detox is strongly recommended.

What is the difference between MAT detox and comfort meds?

MAT (buprenorphine/methadone) eliminates withdrawal. Comfort meds manage individual symptoms without eliminating the core withdrawal.

Disclaimer: Informational only. Not medical advice. SAMHSA: 1-800-662-4357.